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Protective role of mouse mast cell tryptase Mcpt6 in melanoma

Tryptase‐positive mast cells populate melanomas, but it is not known whether tryptase impacts on melanoma progression. Here we addressed this and show that melanoma growth is significantly higher in tryptase‐deficient (Mcpt6(−/−)) versus wild‐type mice. Histochemical analysis showed that mast cells...

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Detalhes bibliográficos
Publicado no:Pigment Cell Melanoma Res
Main Authors: Grujic, Mirjana, Hellman, Lars, Gustafson, Ann‐Marie, Akula, Srinivas, Melo, Fabio Rabelo, Pejler, Gunnar
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317424/
https://ncbi.nlm.nih.gov/pubmed/31894627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/pcmr.12859
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