Whole exome sequencing reveals the maintained polyclonal nature from primary to metastatic malignant peripheral nerve sheath tumor in two patients with NF1

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive soft tissue sarcomas with high metastatic rates and poor overall patient survival. There are currently no effective therapies, underscoring the pressing need to define the molecular etiologies that underlie MPNST progressio...

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Vydáno v:Neurooncol Adv
Hlavní autoři: Godec, Abigail, Jayasinghe, Reyka, Chrisinger, John S A, Prudner, Bethany, Ball, Tyler, Wang, Yuxi, Srihari, Divya, Kaushal, Madhurima, Dietz, Hilary, Zhang, Xiaochun, Pekmezci, Melike, Dahiya, Sonika, Tao, Yu, Luo, Jinqin, Van Tine, Brian A, Ding, Li, Gutmann, David H, Hirbe, Angela C
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2019
Témata:
Supplement Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7317063/
https://ncbi.nlm.nih.gov/pubmed/32642734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdz026
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