Cardioprotective effect of succinate dehydrogenase inhibition in rat hearts and human myocardium with and without diabetes mellitus

Ischemia reperfusion (IR) injury may be attenuated through succinate dehydrogenase (SDH) inhibition by dimethyl malonate (DiMAL). Whether SDH inhibition yields protection in diabetic individuals and translates into human cardiac tissue remain unknown. In isolated perfused hearts from 24 weeks old ma...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Jespersen, Nichlas Riise, Hjortbak, Marie Vognstoft, Lassen, Thomas Ravn, Støttrup, Nicolaj Brejnholt, Johnsen, Jacob, Tonnesen, Pernille Tilma, Larsen, Steen, Kimose, Hans-Henrik, Bøtker, Hans Erik
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316713/
https://ncbi.nlm.nih.gov/pubmed/32587298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67247-4
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