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Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans
While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents. Although there have been attempts to develop fungal-specific inhibitors of dihydrofolate reductase (DHFR),...
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| Veröffentlicht in: | mSphere |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Microbiology
2020
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316490/ https://ncbi.nlm.nih.gov/pubmed/32581079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00374-20 |
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