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Dihydrofolate Reductase Is a Valid Target for Antifungal Development in the Human Pathogen Candida albicans

While the folate biosynthetic pathway has provided a rich source of antibacterial, antiprotozoal, and anticancer therapies, it has not yet been exploited to develop uniquely antifungal agents. Although there have been attempts to develop fungal-specific inhibitors of dihydrofolate reductase (DHFR),...

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Publicado en:mSphere
Main Authors: DeJarnette, Christian, Luna-Tapia, Arturo, Estredge, Leanna R., Palmer, Glen E.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316490/
https://ncbi.nlm.nih.gov/pubmed/32581079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00374-20
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