Secretion of Recombinant Interleukin-22 by Engineered Lactobacillus reuteri Reduces Fatty Liver Disease in a Mouse Model of Diet-Induced Obesity

The incidence of metabolic syndrome continues to rise globally. In mice, intravenous administration of interleukin-22 (IL-22) ameliorates various disease phenotypes associated with diet-induced metabolic syndrome. In patients, oral treatment is favored over intravenous treatment, but methodologies t...

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Bibliographic Details
Published in:mSphere
Main Authors: Oh, Jee-Hwan, Schueler, Kathryn L., Stapleton, Donnie S., Alexander, Laura M., Yen, Chi-Liang Eric, Keller, Mark P., Attie, Alan D., van Pijkeren, Jan-Peter
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316485/
https://ncbi.nlm.nih.gov/pubmed/32581074
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00183-20
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