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Computational and structure-guided design of phosphoinositide substrate specificity into the tyrosine specific LMW-PTP enzyme
We have used a combination of computational and structure-based redesign of the low molecular weight protein tyrosine phosphatase, LMW-PTP, to create new activity towards phosphoinositide substrates for which the wild-type enzyme had little or no activity. The redesigned enzymes retain catalytic act...
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| Publicado no: | PLoS One |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316235/ https://ncbi.nlm.nih.gov/pubmed/32584877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0235133 |
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