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EIF3H orchestrates Hippo pathway-mediated oncogenesis via catalytic control of YAP stability
EIF3H is presumed to be a critical translational initiation factor. Here our unbiased screening for tumor invasion factors has identified an unexpected role for EIF3H as a deubiquitylating enzyme that dictates breast tumor invasion and metastasis by modulating the Hippo-YAP pathway. EIF3H catalyzed...
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| Vydáno v: | Cancer Res |
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| Hlavní autoři: | , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2020
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7316131/ https://ncbi.nlm.nih.gov/pubmed/32269044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-19-3718 |
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