Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins

Pathogenic clostridial species secrete potent toxins that induce severe host tissue damage. Paeniclostridium sordellii lethal toxin (TcsL) causes an almost invariably lethal toxic shock syndrome associated with gynecological infections. TcsL is 87% similar to C. difficile TcdB, which enters host cel...

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Publicado en:Cell
Main Authors: Lee, Hunsang, Beilhartz, Greg L., Kucharska, Iga, Raman, Swetha, Cui, Hong, Lam, Mandy Hiu Yi, Liang, Huazhu, Rubinstein, John L., Schramek, Daniel, Julien, Jean-Philippe, Melnyk, Roman A., Taipale, Mikko
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier Inc. 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7316060/
https://ncbi.nlm.nih.gov/pubmed/32589945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2020.06.005
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