A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

BACKGROUND: Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineage hierarchy, and tumor microenvironment. However, common challenges of PDX mode...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Liu, Zhenyang, Ahn, Michael Ho-Young, Kurokawa, Tomohiro, Ly, Amy, Zhang, Gong, Wang, Fuyou, Yamada, Teppei, Sadagopan, Ananthan, Cheng, Jane, Ferrone, Cristina R., Liss, Andrew S., Honselmann, Kim C., Wojtkiewicz, Gregory R., Ferrone, Soldano, Wang, Xinhui
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315507/
https://ncbi.nlm.nih.gov/pubmed/32580742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02414-9
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