A fast, simple, and cost-effective method of expanding patient-derived xenograft mouse models of pancreatic ductal adenocarcinoma

BACKGROUND: Patient-derived xenograft (PDX) mouse models of cancer have been recognized as better mouse models that recapitulate the characteristics of original malignancies including preserved tumor heterogeneity, lineage hierarchy, and tumor microenvironment. However, common challenges of PDX mode...

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Bibliografiske detaljer
Udgivet i:J Transl Med
Main Authors: Liu, Zhenyang, Ahn, Michael Ho-Young, Kurokawa, Tomohiro, Ly, Amy, Zhang, Gong, Wang, Fuyou, Yamada, Teppei, Sadagopan, Ananthan, Cheng, Jane, Ferrone, Cristina R., Liss, Andrew S., Honselmann, Kim C., Wojtkiewicz, Gregory R., Ferrone, Soldano, Wang, Xinhui
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2020
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315507/
https://ncbi.nlm.nih.gov/pubmed/32580742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02414-9
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