Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure

Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the release of high mobility group box 1 (HMGB1) and the interaction with receptor...

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Détails bibliographiques
Publié dans:Sci Transl Med
Auteurs principaux: Arnold, Katelyn, Xu, Yongmei, Sparkenbaugh, Erica M., Li, Miaomiao, Han, Xiaorui, Zhang, Xing, Xia, Ke, Piegore, Mark, Zhang, Fuming, Zhang, Xiaoxiao, Henderson, Mike, Pagadala, Vijayakanth, Su, Guowei, Tan, Lisi, Park, Pyong Woo, Stravitz, Richard T., Key, Nigel S., Linhardt, Robert J., Pawlinski, Rafal, Xu, Ding, Liu, Jian
Format: Artigo
Langue:Inglês
Publié: 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315409/
https://ncbi.nlm.nih.gov/pubmed/32188725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav8075
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