Design of anti-inflammatory heparan sulfate to protect against acetaminophen-induced acute liver failure

Acetaminophen/paracetamol (APAP) overdose is the leading cause of drug-induced acute liver failure (ALF) in the United States and Europe. The progression of the disease is attributed to sterile inflammation induced by the release of high mobility group box 1 (HMGB1) and the interaction with receptor...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Transl Med
Egile Nagusiak: Arnold, Katelyn, Xu, Yongmei, Sparkenbaugh, Erica M., Li, Miaomiao, Han, Xiaorui, Zhang, Xing, Xia, Ke, Piegore, Mark, Zhang, Fuming, Zhang, Xiaoxiao, Henderson, Mike, Pagadala, Vijayakanth, Su, Guowei, Tan, Lisi, Park, Pyong Woo, Stravitz, Richard T., Key, Nigel S., Linhardt, Robert J., Pawlinski, Rafal, Xu, Ding, Liu, Jian
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7315409/
https://ncbi.nlm.nih.gov/pubmed/32188725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav8075
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