Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation

The functional relevance and mechanistic basis of the effects of the pyroptosis executioner Gasdermin D (GSDMD) on colitis remain unclear. In this study, we observed that GSDMD protein was activated during intestinal inflammation in a model of chemically induced colitis. GSDMD deficiency exacerbated...

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Publicat a:Sci Adv
Autors principals: Ma, Chunmei, Yang, Dongxue, Wang, Bingwei, Wu, Chunyan, Wu, Yuqing, Li, Sheng, Liu, Xue, Lassen, Kara, Dai, Lue, Yang, Shuo
Format: Artigo
Idioma:Inglês
Publicat: American Association for the Advancement of Science 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314554/
https://ncbi.nlm.nih.gov/pubmed/32671214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6717
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