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Gasdermin D in macrophages restrains colitis by controlling cGAS-mediated inflammation
The functional relevance and mechanistic basis of the effects of the pyroptosis executioner Gasdermin D (GSDMD) on colitis remain unclear. In this study, we observed that GSDMD protein was activated during intestinal inflammation in a model of chemically induced colitis. GSDMD deficiency exacerbated...
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| Publicado no: | Sci Adv |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7314554/ https://ncbi.nlm.nih.gov/pubmed/32671214 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aaz6717 |
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