Germline burden of rare damaging variants negatively affects human healthspan and lifespan

Heritability of human lifespan is 23–33% as evident from twin studies. Genome-wide association studies explored this question by linking particular alleles to lifespan traits. However, genetic variants identified so far can explain only a small fraction of lifespan heritability in humans. Here, we r...

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Bibliografiske detaljer
Udgivet i:eLife
Main Authors: Shindyapina, Anastasia V, Zenin, Aleksandr A, Tarkhov, Andrei E, Santesmasses, Didac, Fedichev, Peter O, Gladyshev, Vadim N
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2020
Fag:
Human Biology and Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314550/
https://ncbi.nlm.nih.gov/pubmed/32254024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53449
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