Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-Nfkb interactions

The neurotoxicity of air pollution is undefined for sex and APOE alleles. These major risk factors of Alzheimer’s disease (AD) were examined in mice given chronic exposure to nPM, a nano-sized subfraction of urban air pollution. In the cerebral cortex, female mice had two-fold more genes responding...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Haghani, Amin, Cacciottolo, Mafalda, Doty, Kevin R, D'Agostino, Carla, Thorwald, Max, Safi, Nikoo, Levine, Morgan E, Sioutas, Constantinos, Town, Terrence C, Forman, Henry Jay, Zhang, Hongqiao, Morgan, Todd E, Finch, Caleb E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Computational and Systems Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314548/
https://ncbi.nlm.nih.gov/pubmed/32579111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54822
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