The histone modification reader ZCWPW1 links histone methylation to PRDM9-induced double-strand break repair

The histone modification writer Prdm9 has been shown to deposit H3K4me3 and H3K36me3 at future double-strand break (DSB) sites during the very early stages of meiosis, but the reader of these marks remains unclear. Here, we demonstrate that Zcwpw1 is an H3K4me3 reader that is required for DSB repair...

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Veröffentlicht in:eLife
Hauptverfasser: Huang, Tao, Yuan, Shenli, Gao, Lei, Li, Mengjing, Yu, Xiaochen, Zhan, Jianhong, Yin, Yingying, Liu, Chao, Zhang, Chuanxin, Lu, Gang, Li, Wei, Liu, Jiang, Chen, Zi-Jiang, Liu, Hongbin
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2020
Schlagworte:
Cell Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314539/
https://ncbi.nlm.nih.gov/pubmed/32374261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.53459
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