Structural and chemical trapping of flavin‐oxide intermediates reveals substrate‐directed reaction multiplicity

Though reactive flavin‐N5/C4α‐oxide intermediates can be spectroscopically profiled for some flavin‐assisted enzymatic reactions, their exact chemical configurations are hardly visualized. Structural systems biology and stable isotopic labelling techniques were exploited to correct this stereotypica...

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Dettagli Bibliografici
Pubblicato in:Protein Sci
Autori principali: Lin, Kuan‐Hung, Lyu, Syue‐Yi, Yeh, Hsien‐Wei, Li, Yi‐Shan, Hsu, Ning‐Shian, Huang, Chun‐Man, Wang, Yung‐Lin, Shih, Hao‐Wei, Wang, Zhe‐Chong, Wu, Chang‐Jer, Li, Tsung‐Lin
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley & Sons, Inc. 2020
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Full‐length Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7314388/
https://ncbi.nlm.nih.gov/pubmed/32362037
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3879
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