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Trapping of an intermediate in the reaction catalyzed by flavin-dependent thymidylate synthase (FDTS)
Thymidylate is a DNA nucleotide that is essential to all organisms and is synthesized by the enzyme thymidylate synthase (TSase). Several human pathogens rely on an alternative flavin-dependent thymidylate synthase (FDTS), which differs from the human TSase both in structure and molecular mechanism....
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3296878/ https://ncbi.nlm.nih.gov/pubmed/22295882 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2120822 |
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