Apolipoprotein E triggers complement activation in joint synovial fluid of rheumatoid arthritis patients by binding C1q

We identified apolipoprotein E (ApoE) as one of the proteins that are found in complex with complement component C4d in pooled synovial fluid of rheumatoid arthritis (RA) patients. Immobilized human ApoE activated both the classical and the alternative complement pathways. In contrast, ApoE in solut...

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Detalhes bibliográficos
Publicado no:J Immunol
Principais autores: Vogt, Leonie M., Kwasniewicz, Ewa, Talens, Simone, Scavenius, Carsten, Bielecka, Ewa, Ekdahl, Kristina N., Enghild, Jan J., Mörgelin, Matthias, Saxne, Tore, Potempa, Jan, Blom, Anna M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313146/
https://ncbi.nlm.nih.gov/pubmed/32253242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1900372
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