Carbamylation of immunoglobulin abrogates activation of the classical complement pathway

Post-translational modifications of proteins significantly affect their structure and function. The carbamylation of positively charged lysine residues to form neutral homoitrulline occurs primarily under inflammatory conditions through myeloperoxidase-dependent cyanate (CNO(−)) formation. We analyz...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Koro, Catalin, Bielecka, Ewa, Dahl-Knudsen, Anders, Enghild, Jan J, Scavenius, Carsten, Brun, Johan G, Binder, Veronika, Hellvard, Annelie, Bergum, Brith, Jonsson, Roland, Potempa, Jan, Blom, Anna M, Mydel, Piotr
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Molecular Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4232992/
https://ncbi.nlm.nih.gov/pubmed/25130613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444869
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