WT1 facilitates the self-renewal of leukemia-initiating cells through the upregulation of BCL2L2: WT1-BCL2L2 axis as a new acute myeloid leukemia therapy target

BACKGROUND: Overexpression of Wilms’ tumor-1 (WT1) transcription factor facilitates proliferation in acute myeloid leukemia (AML). However, whether WT1 is enriched in the leukemia-initiating cells (LICs) and leukemia stem cells (LSCs) and facilitates the self-renewal of LSCs remains poorly understoo...

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Dades bibliogràfiques
Publicat a:J Transl Med
Autors principals: Zhou, Bin, Jin, Xianghong, Jin, Weiwei, Huang, Xingzhou, Wu, Yanfei, Li, Haiying, Zhu, Weijian, Qin, Xiaoyi, Ye, Haige, Gao, Shenmeng
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2020
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313134/
https://ncbi.nlm.nih.gov/pubmed/32580769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-020-02384-y
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