High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer

BACKGROUND: Not merely the onset of immune evasion, but other factors, such as acidosis and fibrosis, are also major barriers in cancer therapeutics. Dense fibrosis is a hallmark of pancreatic ductal carcinoma (PDAC), in which hyperactivation of focal adhesion kinase (FAK) in tumor cells was shown t...

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Detalhes bibliográficos
Publicado no:Cell Commun Signal
Main Authors: Tsutaho, Akio, Hashimoto, Ari, Hashimoto, Shigeru, Hata, Soichiro, Kachi, Shion, Hirano, Satoshi, Sabe, Hisataka
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7313132/
https://ncbi.nlm.nih.gov/pubmed/32580737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12964-020-00608-8
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