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Electrostatic Interactions Govern Extreme Nascent Protein Ejection Times from Ribosomes and Can Delay Ribosome Recycling

The ejection of nascent proteins out of the ribosome exit tunnel, after their covalent bond to transfer-RNA has been broken, has not been experimentally studied due to challenges in sample preparation. Here, we investigate this process using a combination of multiscale modeling, ribosome profiling,...

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Detalles Bibliográficos
Publicado en:J Am Chem Soc
Main Authors: Nissley, Daniel A., Vu, Quyen V., Trovato, Fabio, Ahmed, Nabeel, Jiang, Yang, Suan Li, Mai, O’Brien, Edward P.
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312765/
https://ncbi.nlm.nih.gov/pubmed/32138505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.9b12264
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