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Cell-Clearing Systems Bridging Repeat Expansion Proteotoxicity and Neuromuscular Junction Alterations in ALS and SBMA

The coordinated activities of autophagy and the ubiquitin proteasome system (UPS) are key to preventing the aggregation and toxicity of misfold-prone proteins which manifest in a number of neurodegenerative disorders. These include proteins which are encoded by genes containing nucleotide repeat exp...

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Bibliographic Details
Published in:Int J Mol Sci
Main Authors: Limanaqi, Fiona, Busceti, Carla Letizia, Biagioni, Francesca, Cantini, Federica, Lenzi, Paola, Fornai, Francesco
Format: Artigo
Language:Inglês
Published: MDPI 2020
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7312203/
https://ncbi.nlm.nih.gov/pubmed/32512809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21114021
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