HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma (CCA). We previously showed primary cilia have tumor suppressor characteristics, and HDAC6 is involved in ciliary loss. However, mechanisms of ciliary disassembly are unknown. Herein, we tested the hypothesis that...

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Detalhes bibliográficos
Publicado no:Am J Physiol Gastrointest Liver Physiol
Main Authors: Peixoto, Estanislao, Jin, Sujeong, Thelen, Kristen, Biswas, Aalekhya, Richard, Seth, Morleo, Manuela, Mansini, Adrian, Holtorf, Stephanie, Carbone, Fabrizia, Pastore, Nunzia, Ballabio, Andrea, Franco, Brunella, Gradilone, Sergio A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311663/
https://ncbi.nlm.nih.gov/pubmed/32338033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00033.2020
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