HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma (CCA). We previously showed primary cilia have tumor suppressor characteristics, and HDAC6 is involved in ciliary loss. However, mechanisms of ciliary disassembly are unknown. Herein, we tested the hypothesis that...

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Bibliografische gegevens
Gepubliceerd in:Am J Physiol Gastrointest Liver Physiol
Hoofdauteurs: Peixoto, Estanislao, Jin, Sujeong, Thelen, Kristen, Biswas, Aalekhya, Richard, Seth, Morleo, Manuela, Mansini, Adrian, Holtorf, Stephanie, Carbone, Fabrizia, Pastore, Nunzia, Ballabio, Andrea, Franco, Brunella, Gradilone, Sergio A.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Physiological Society 2020
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311663/
https://ncbi.nlm.nih.gov/pubmed/32338033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00033.2020
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