HDAC6-dependent ciliophagy is involved in ciliary loss and cholangiocarcinoma growth in human cells and murine models

Reduced ciliary expression is reported in several tumors, including cholangiocarcinoma (CCA). We previously showed primary cilia have tumor suppressor characteristics, and HDAC6 is involved in ciliary loss. However, mechanisms of ciliary disassembly are unknown. Herein, we tested the hypothesis that...

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Vydáno v:Am J Physiol Gastrointest Liver Physiol
Hlavní autoři: Peixoto, Estanislao, Jin, Sujeong, Thelen, Kristen, Biswas, Aalekhya, Richard, Seth, Morleo, Manuela, Mansini, Adrian, Holtorf, Stephanie, Carbone, Fabrizia, Pastore, Nunzia, Ballabio, Andrea, Franco, Brunella, Gradilone, Sergio A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311663/
https://ncbi.nlm.nih.gov/pubmed/32338033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00033.2020
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