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The hydrolytic water molecule of Class A β-lactamase relies on the acyl-enzyme intermediate ES* for proper coordination and catalysis

Serine-based β-lactamases of Class A, C and D all rely on a key water molecule to hydrolyze and inactivate β-lactam antibiotics. This process involves two conserved catalytic steps. In the first acylation step, the β-lactam antibiotic forms an acyl-enzyme intermediate (ES*) with the catalytic serine...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: He, Yunjiao, Lei, Jinping, Pan, Xuehua, Huang, Xuhui, Zhao, Yanxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311446/
https://ncbi.nlm.nih.gov/pubmed/32576842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66431-w
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