Tumor-specific, near-infrared nanobody probe rapidly labels tumors in an orthotopic mouse model of pancreatic cancer

BACKGROUND: Nanobodies, derived from camelid antibodies made of only heavy chains, are the smallest, biologic, antigen-binding fragments (~15kDa) with faster pharmacokinetics and better tumor penetration efficiency than standard antibodies. The present study evaluates the efficacy of a fluorescent,...

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Detalhes bibliográficos
Publicado no:Surgery
Main Authors: Lwin, Thinzar M., Hernot, Sophie, Hollandsworth, Hannah, Amirfakhri, Siamak, Filemoni, Filemoni, Debie, Pieterjan, Hoffman, Robert M., Bouvet, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7311276/
https://ncbi.nlm.nih.gov/pubmed/32370916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2020.02.020
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