Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models

PURPOSE: We assessed whether mitomycin-C (MMC) has different antifibrotic mechanisms in trabeculectomy wound healing. METHODS: We identified 2 concentrations of MMC as “low-dose” by using WST-1 assay, Lactic dehydrogenase assay, and fluorescence-activated cell sorting flow cytometry. Senescence-asso...

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Vydáno v:PLoS One
Hlavní autoři: Lin, Le-Tien, Chen, Jiann-Torng, Lu, Da-Wen, Tai, Ming-Cheng, Liang, Chang-Min, Chen, Ching-Long, Pao, Shu-I, Hsu, Chih-Kang, Chen, Yi-Hao
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310836/
https://ncbi.nlm.nih.gov/pubmed/32574191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0234706
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