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Intrafamilial phenotypic variation in spinocerebellar ataxia type 23

BACKGROUND: Spinocerebellar ataxia type 23 (SCA23) is an autosomal dominant cerebellar ataxia caused by pathogenic variants in the prodynorphin gene (PDYN). The frequency of PDYN variants is reportedly very low (~ 0.1%) in several ataxia cohorts screened to date. CASE PRESENTATIONS: We found five ca...

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Detalhes bibliográficos
Publicado no:Cerebellum Ataxias
Main Authors: Satoh, Shunichi, Kondo, Yasufumi, Ohara, Shinji, Yamaguchi, Tomomi, Nakamura, Katsuya, Yoshida, Kunihiro
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7310450/
https://ncbi.nlm.nih.gov/pubmed/32587707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40673-020-00117-x
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