Arrayed CRISPR Screening Identifies Novel Targets That Enhance the Productive Delivery of mRNA by MC3-Based Lipid Nanoparticles

Modified messenger RNAs (mRNAs) hold great potential as therapeutics by using the body’s own processes for protein production. However, a key challenge is efficient delivery of therapeutic mRNA to the cell cytosol and productive protein translation. Lipid nanoparticles (LNPs) are the most clinically...

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Detalhes bibliográficos
Publicado no:SLAS Discov
Main Authors: Ross-Thriepland, Douglas, Bornot, Aurelie, Butler, Larissa, Desai, Arpan, Jaiswal, Himjyot, Peel, Samantha, Hunter, Morag Rose, Odunze, Uchechukwu, Isherwood, Beverley, Gianni, Davide
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309353/
https://ncbi.nlm.nih.gov/pubmed/32441189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555220925770
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