The Staphylococcus aureus IsdH Receptor Forms a Dynamic Complex with Human Hemoglobin that Triggers Heme Release via Two Distinct Hot Spots

Iron is an essential nutrient that is actively acquired by bacterial pathogens during infections. Clinically important Staphylococcus aureus obtains iron by extracting heme from hemoglobin (Hb) using the closely related IsdB and IsdH surface receptors. In IsdH, extraction is mediated by a conserved...

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Veröffentlicht in:J Mol Biol
Hauptverfasser: Ellis-Guardiola, Ken, Clayton, Joseph, Pham, Clarissa, Mahoney, Brendan J., Wereszczynski, Jeff, Clubb, Robert T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7309296/
https://ncbi.nlm.nih.gov/pubmed/31881209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2019.12.023
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