The Staphylococcus aureus Protein IsdH Inhibits Host Hemoglobin Scavenging to Promote Heme Acquisition by the Pathogen

Hemolysis is a complication in septic infections with Staphylococcus aureus, which utilizes the released Hb as an iron source. S. aureus can acquire heme in vitro from hemoglobin (Hb) by a heme-sequestering mechanism that involves proteins from the S. aureus iron-regulated surface determinant (Isd)...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Sæderup, Kirstine Lindhardt, Stødkilde, Kristian, Graversen, Jonas Heilskov, Dickson, Claire F., Etzerodt, Anders, Hansen, Søren Werner Karlskov, Fago, Angela, Gell, David, Andersen, Christian Brix Folsted, Moestrup, Søren Kragh
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Membrane Biology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5104924/
https://ncbi.nlm.nih.gov/pubmed/27681593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755934
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