Structure of the Hemoglobin-IsdH Complex Reveals the Molecular Basis of Iron Capture by Staphylococcus aureus

Staphylococcus aureus causes life-threatening disease in humans. The S. aureus surface protein iron-regulated surface determinant H (IsdH) binds to mammalian hemoglobin (Hb) and extracts heme as a source of iron, which is an essential nutrient for the bacteria. However, the process of heme transfer...

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Main Authors: Dickson, Claire F., Kumar, Kaavya Krishna, Jacques, David A., Malmirchegini, G. Reza, Spirig, Thomas, Mackay, Joel P., Clubb, Robert T., Guss, J. Mitchell, Gell, David A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Protein Structure and Folding
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3945333/
https://ncbi.nlm.nih.gov/pubmed/24425866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.545566
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