NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation

Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the dose‐limiting toxicity of combined treatments on the...

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Bibliografische gegevens
Gepubliceerd in:Stem Cells Transl Med
Hoofdauteurs: Giuranno, Lorena, Roig, Eloy M., Wansleeben, Carolien, van den Berg, Annette, Groot, Arjan J., Dubois, Ludwig, Vooijs, Marc
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: John Wiley & Sons, Inc. 2020
Onderwerpen:
Tissue‐specific Progenitor and Stem Cells
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308641/
https://ncbi.nlm.nih.gov/pubmed/32297712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.19-0278
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