NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation

Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the dose‐limiting toxicity of combined treatments on the...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Stem Cells Transl Med
Главные авторы: Giuranno, Lorena, Roig, Eloy M., Wansleeben, Carolien, van den Berg, Annette, Groot, Arjan J., Dubois, Ludwig, Vooijs, Marc
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley & Sons, Inc. 2020
Предметы:
Tissue‐specific Progenitor and Stem Cells
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308641/
https://ncbi.nlm.nih.gov/pubmed/32297712
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.19-0278
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы