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NOTCH inhibition promotes bronchial stem cell renewal and epithelial barrier integrity after irradiation
Hyperactivity of the NOTCH pathway is associated with tumor growth and radiotherapy resistance in lung cancer, and NOTCH/γ‐secretase inhibitors (GSIs) are a potential therapeutic target. The therapeutic outcome, however, is often restricted by the dose‐limiting toxicity of combined treatments on the...
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| Publicado no: | Stem Cells Transl Med |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley & Sons, Inc.
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308641/ https://ncbi.nlm.nih.gov/pubmed/32297712 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sctm.19-0278 |
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