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Endothelial-specific Crif1 deletion induces BBB maturation and disruption via the alteration of actin dynamics by impaired mitochondrial respiration

Cerebral endothelial cells (ECs) require junctional proteins to maintain blood–brain barrier (BBB) integrity, restricting toxic substances and controlling peripheral immune cells with a higher concentration of mitochondria than ECs of peripheral capillaries. The mechanism underlying BBB disruption b...

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Detalhes bibliográficos
Publicado no:J Cereb Blood Flow Metab
Main Authors: Lee, Min Joung, Jang, Yunseon, Han, Jeongsu, Kim, Soo J, Ju, Xianshu, Lee, Yu Lim, Cui, Jianchen, Zhu, Jiebo, Ryu, Min Jeong, Choi, Song-Yi, Chung, Woosuk, Heo, Chaejeong, Yi, Hyon-Seung, Kim, Hyun Jin, Huh, Yang H, Chung, Sookja K, Shong, Minho, Kweon, Gi-Ryang, Heo, Jun Young
Formato: Artigo
Idioma:Inglês
Publicado em: SAGE Publications 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308523/
https://ncbi.nlm.nih.gov/pubmed/31987007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0271678X19900030
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