DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner

Efficient repair of DNA double-strand breaks (DSBs) requires a coordinated DNA Damage Response (DDR), which includes phosphorylation of histone H2Ax, forming γH2Ax. This histone modification spreads beyond the DSB into neighboring chromatin, generating a DDR platform that protects against end disass...

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Udgivet i:Nat Commun
Main Authors: Collins, Patrick L., Purman, Caitlin, Porter, Sofia I., Nganga, Vincent, Saini, Ankita, Hayer, Katharina E., Gurewitz, Greer L., Sleckman, Barry P., Bednarski, Jeffrey J., Bassing, Craig H., Oltz, Eugene M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308414/
https://ncbi.nlm.nih.gov/pubmed/32572033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-16926-x
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