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Catechol-O-methyltransferase rs4680 and rs4818 haplotype association with treatment response to olanzapine in patients with schizophrenia

Antipsychotic drugs target primarily dopaminergic system which makes catechol-O-methyltransferase (COMT) an interesting target in studies searching for treatment response predictors in schizophrenia. The study assessed the association of the COMT rs4680 and rs4818 polymorphisms with therapeutic resp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Nikolac Perkovic, Matea, Sagud, Marina, Zivkovic, Maja, Uzun, Suzana, Nedic Erjavec, Gordana, Kozumplik, Oliver, Svob Strac, Dubravka, Mimica, Ninoslav, Mihaljevic Peles, Alma, Pivac, Nela
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308339/
https://ncbi.nlm.nih.gov/pubmed/32572118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-67351-5
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