Haplotypic and Genotypic Association of Catechol-O-Methyltransferase rs4680 and rs4818 Polymorphisms and Treatment Resistance in Schizophrenia

Treatment-resistant schizophrenia (TRS) continues to be a challenge. It was related to different factors, including alterations in the activity of brain dopaminergic system, which could be influenced by the dopamine-degrading enzyme, catechol-O-methyltransferase (COMT). Variants of the COMT gene hav...

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Detalhes bibliográficos
Publicado no:Front Pharmacol
Main Authors: Sagud, Marina, Tudor, Lucija, Uzun, Suzana, Perkovic, Matea Nikolac, Zivkovic, Maja, Konjevod, Marcela, Kozumplik, Oliver, Vuksan Cusa, Bjanka, Svob Strac, Dubravka, Rados, Iva, Mimica, Ninoslav, Mihaljevic Peles, Alma, Nedic Erjavec, Gordana, Pivac, Nela
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6037851/
https://ncbi.nlm.nih.gov/pubmed/30018555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00705
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