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Adeno-associated virus-binding antibodies detected in cats living in the Northeastern United States lack neutralizing activity

Cats are a critical pre-clinical model for studying adeno-associated virus (AAV) vector-mediated gene therapies. A recent study has described the high prevalence of anti-AAV neutralizing antibodies among domestic cats in Switzerland. However, our knowledge of pre-existing humoral immunity against va...

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Bibliografiska uppgifter
I publikationen:Sci Rep
Huvudupphovsmän: Adachi, Kei, Dissen, Gregory A., Lomniczi, Alejandro, Xie, Qing, Ojeda, Sergio R., Nakai, Hiroyuki
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308316/
https://ncbi.nlm.nih.gov/pubmed/32572045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66596-4
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