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Drawing a high-resolution functional map of adeno-associated virus capsid by massively parallel sequencing
Adeno-associated virus (AAV) capsid engineering is an emerging approach to advance gene therapy. However, a systematic analysis on how each capsid amino acid contributes to multiple functions remains challenging. Here we show proof-of-principle and successful application of a novel approach, termed...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Pub. Group
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3941020/ https://ncbi.nlm.nih.gov/pubmed/24435020 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4075 |
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