Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors

Brain GABA(Α) receptors are ionotropic receptors belonging to the class of Cys-loop receptors and are important drug targets for the treatment of anxiety and sleep disorders. By screening a compound library (2,112 compounds) at recombinant human α(4)β(1)δ GABA(Α) receptors heterologously expressed i...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Falk-Petersen, Christina Birkedahl, Tsonkov, Tsonko M., Nielsen, Malene Sofie, Harpsøe, Kasper, Bundgaard, Christoffer, Frølund, Bente, Kristiansen, Uffe, Gloriam, David E., Wellendorph, Petrine
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308271/
https://ncbi.nlm.nih.gov/pubmed/32572053
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66821-0
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