New Synthesis and Tritium Labeling of a Selective Ligand for Studying High-affinity γ-Hydroxybutyrate (GHB) Binding Sites

3-Hydroxycyclopent-1-enecarboxylic acid (HOCPCA, 1) is a potent ligand for the high-affinity GHB binding sites in the CNS. An improved synthesis of 1 together with a very efficient synthesis of [(3)H]-1 is described. The radiosynthesis employs in situ generated lithium trimethoxyborotritide. Screeni...

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Main Authors: Vogensen, Stine B., Marek, Aleš, Bay, Tina, Wellendorph, Petrine, Kehler, Jan, Bundgaard, Christoffer, Frølund, Bente, Pedersen, Martin H.F., Clausen, Rasmus P.
Format: Artigo
Jezik:Inglês
Izdano: 2013
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3888956/
https://ncbi.nlm.nih.gov/pubmed/24053696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm4011719
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