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Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA(A) receptors
Brain GABA(Α) receptors are ionotropic receptors belonging to the class of Cys-loop receptors and are important drug targets for the treatment of anxiety and sleep disorders. By screening a compound library (2,112 compounds) at recombinant human α(4)β(1)δ GABA(Α) receptors heterologously expressed i...
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| Publicat a: | Sci Rep |
|---|---|
| Autors principals: | , , , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group UK
2020
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7308271/ https://ncbi.nlm.nih.gov/pubmed/32572053 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-66821-0 |
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