Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) syn...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Macchi, Magali, Magalon, Karine, Zimmer, Céline, Peeva, Elitsa, El Waly, Bilal, Brousse, Béatrice, Jaekel, Sarah, Grobe, Kay, Kiefer, Friedemann, Williams, Anna, Cayre, Myriam, Durbec, Pascale
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2020
Aiheet:
Neuroscience
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308090/
https://ncbi.nlm.nih.gov/pubmed/32515730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51735
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