Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) syn...

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Detalles Bibliográficos
Publicado en:eLife
Main Authors: Macchi, Magali, Magalon, Karine, Zimmer, Céline, Peeva, Elitsa, El Waly, Bilal, Brousse, Béatrice, Jaekel, Sarah, Grobe, Kay, Kiefer, Friedemann, Williams, Anna, Cayre, Myriam, Durbec, Pascale
Formato: Artigo
Idioma:Inglês
Publicado: eLife Sciences Publications, Ltd 2020
Assuntos:
Neuroscience
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308090/
https://ncbi.nlm.nih.gov/pubmed/32515730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51735
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