Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) syn...

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Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Macchi, Magali, Magalon, Karine, Zimmer, Céline, Peeva, Elitsa, El Waly, Bilal, Brousse, Béatrice, Jaekel, Sarah, Grobe, Kay, Kiefer, Friedemann, Williams, Anna, Cayre, Myriam, Durbec, Pascale
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2020
Onderwerpen:
Neuroscience
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308090/
https://ncbi.nlm.nih.gov/pubmed/32515730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51735
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