Mature oligodendrocytes bordering lesions limit demyelination and favor myelin repair via heparan sulfate production

Myelin destruction is followed by resident glia activation and mobilization of endogenous progenitors (OPC) which participate in myelin repair. Here we show that in response to demyelination, mature oligodendrocytes (OLG) bordering the lesion express Ndst1, a key enzyme for heparan sulfates (HS) syn...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Macchi, Magali, Magalon, Karine, Zimmer, Céline, Peeva, Elitsa, El Waly, Bilal, Brousse, Béatrice, Jaekel, Sarah, Grobe, Kay, Kiefer, Friedemann, Williams, Anna, Cayre, Myriam, Durbec, Pascale
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2020
Gaiak:
Neuroscience
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7308090/
https://ncbi.nlm.nih.gov/pubmed/32515730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.51735
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